I am sure you have seen this error message when you try to run an executable file over the network in Windows 2003 (and up) servers.
Reason: It’s because Windows 2003 (and up) servers open the network location as "Internet" classification by default. (Remember Internet Explorer is embedded into OS level).
Solution 1: It may not work with all the latest patches. Right click on the executable file and open Properties. Click "Unblock" button. Close the dialog box and try running the executable.
Solution 2: Copy the Executable and all needed files locally to the server and run it.
Solution 3: If you are going to run many executables repeatedly from a same network location, follow the steps.
a. On your Explorer window, enable the Status Bar by click "View" Menu and select "Status Bar".
b. On the Status bar (bottom of the window), look for Internet globe icon and double click it.
c. Click on "Trusted Sites" and click on "Sites" button. Add your network location. Click Close and OK to close the location.
d. That’s it. You can free to run any executable from this location here after.
Hope these solution helps to do your job.